11/16/25 06:23:00
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11/16 18:21 CST Brock Purdy throws 3 TDs in return from toe injury, 49ers
cruise to 41-22 win over sloppy Cardinals
Brock Purdy throws 3 TDs in return from toe injury, 49ers cruise to 41-22 win
over sloppy Cardinals
By DAVID BRANDT
AP Sports Writer
GLENDALE, Ariz. (AP) --- Brock Purdy threw three touchdown passes in his return
from a toe injury, Christian McCaffrey had two rushing touchdowns and a
receiving score, and the San Francisco 49ers beat the sloppy Arizona Cardinals
41-22 on Sunday.
McCaffrey extended his NFL record with his 17th career game with at least one
running touchdown and a touchdown catch. Purdy completed 19 of 26 passes for
200 yards.
Tight end George Kittle caught two touchdown passes.
Arizona lost for the sixth time in seven games. The Cardinals were called for a
franchise-record 17 penalties, which was also the most for any team in the NFL
this season. They had 11 penalties in the first half --- tied for the most
before halftime for any team over the past 20 years.
Arizona's Jacoby Brissett started his fifth straight game for the injured Kyler
Murray and completed 47 of 57 passes for 452 yards, two touchdowns and two
interceptions. The 47 completions set an NFL record in the regular season.
Michael Wilson caught 15 passes for a career-high 185 yards. Tight end Trey
McBride had 115 yards receiving and a touchdown.
The 49ers (7-4) had control from the outset, needing just 16 seconds to take a
7-0 lead. Skyy Moore returned the opening kickoff 98 yards to the Arizona 1,
setting up a 1-yard touchdown run by McCaffrey on the next play.
Purdy returned after being sidelined for six straight games because of the toe
injury and was playing his first game since Sept. 28.
He didn't appear to have much rust: The 25-year-old misfired on his first
throw, but then completed three straight passes, including a beautifully-thrown
30-yard touchdown to Kittle for a 13-0 lead with 9:51 left in the first quarter.
For the Cardinals, it was an eerily similar start to last week's debacle
against the Seattle Seahawks, when they fell into a 35-0 hole in the first half
before losing 44-22.
Arizona (3-7) had a slightly quicker response against San Francisco, cutting
the margin to 13-7 later in the first on Bam Knight's 6-yard touchdown run, but
the good times didn't last very long. The 49ers pushed ahead 19-7 early in the
second quarter when Purdy hit a wide open McCaffrey for a 9-yard score.
Eddy Pieiro made a 47-yard field goal as time expired in the second quarter to
give the 49ers a 25-10 halftime lead. Pieiro initially had his 62-yard attempt
blocked on the previous play, but Arizona's Calais Campbell was called for a
15-yard penalty for unnecessary roughness, giving the kicker another chance.
The Cardinals continued to make critical errors in the second half. Knight
looked like he had a 60-yard touchdown run in the third quarter, but it was
called back because of a holding penalty on tight end Pharaoh Brown.
Injuries
49ers: DE Robert Beal Jr. left with a concussion. LB Tatum Bethune (ankle) and
defensive back Upton Stout (stinger) left the game in the second quarter.
Pieiro (hamstring) left in the third.
Cardinals: Receiver Marvin Harrison Jr., who had surgery for appendicitis
earlier this week, was among seven inactives. RB Emari Demercado (ankle) left
the game in the second quarter. CB Garrett Williams (shin) left in the third.
RT Kelvin Beachum (groin) left in the fourth.
Up next
49ers: Host Carolina on Monday, Nov. 24.
Cardinals: Host Jacksonville next Sunday.
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AP NFL: https://apnews.com/hub/nfl
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